Children's Hospital of Michigan, in conjunction with the Detroit Medical Center and Wayne State University is conducting a Pediatric Sickle Cell Research Study called Baby Hug. Hydroxyurea, a mild chemotherapy drug initially used to treat certain cancers, will be studied in very young children with Sickle Cell Anemia. BABY HUG will enroll a total of 200 infants with sickle cell disease from 14 major sickle cell programs in the United States.